The star poses in an enormous boxy double breasted jacket, black hat and scarf tied around her eyes. Her wide open mouth shows a bizarre grille in her teeth, making them look oversized.
The jacket is cropped at the waist and the 27-year-old singer also sports black underwear with mysterious bruises around the crotch area.
Bizarre: Lady Gaga released the bizarre artwork for her new single Dope on Thursday
The enormous boxy jacket appeared to be inspired by the cover of Talking Heads album Stop Making Sense.
The star revealed via her Twitter account that her new single will be released on November 4.
It also features on her forthcoming new album ARTPOP.
'Dope will be available 12:01am local time Nov 4th,' she wrote. 'Final song available for purchase before ARTPOP release Nov 11.'
Gaga has recently been in London to promote ARTPOP where she has been seen in a series of typically eccentric outfits.
Eclectic: Gaga sports an oversize boxy jacket, black underwear, a black boot, hat and strange oversized false teeth
When asked whether or not she considers herself to be beautiful, the star had a very self-aware response.